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A comparative account of protein-protein interaction resources, feature-validations and application-based categorizations : Viral-host PPIs
S.NoResources Important features / utilities*CitationsYear of publicationRank by usage frequency Click to Edit / Add comments
1 IntAct
A database that provides protein-protein interactions of experimental importance. Protein-protein interactions for few specific diseases are available. Protein interactions specific to a biological process (e.g., apoptosis, cell cycle) can also be obtained. Provides interactions along with their functional associations. Interactions can be restricted to a given experimental evidence. Provides interactions related to cancer. Provides protein-drug interactions. User interaface parameters can be implied to the input.
Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A, Margalit H, Armstrong J, Bairoch A, Cesareni G, Sherman D, Apweiler R. IntAct: an open source molecular interaction database. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D452-5. PubMed PMID: 14681455; PubMed Central PMCID: PMC308786.
2 BIND/BOND - Biomolecular Object Network Databank
A database of protein-domain/ domain-domain interactions. Provides PPIs for a specific disease (e.g., prostate cancer). Provides protein-small molecule, protein-nucleic acid & genetic interactions. Provides the interactions along with the complexes and pathways involved. Also provides viral-human protein interactions (e.g., HIV-host protein interactions).
Bader GD, Donaldson I, Wolting C, Ouellette BF, Pawson T, Hogue CW. BIND--The Biomolecular Interaction Network Database. Nucleic Acids Res. 2001 Jan 1;29(1):242-5. PubMed PMID: 11125103; PubMed Central PMCID: PMC29820.
3 MINT - Molecular INTeraction
A database that provides PPIs of experimental importance. It also identifies interactions among the given list of proteins. Provides options to curate data for the database.
Zanzoni A, Montecchi-Palazzi L, Quondam M, Ausiello G, Helmer-Citterich M, Cesareni G. MINT: a Molecular INTeraction database. FEBS Lett. 2002 Feb 20;513(1):135-40. Review. PubMed PMID: 11911893.
4 VirHostNet
A database specific to viral-human protein interactions. Provides option for uploading or submitting PPI data.
Navratil V, de Chassey B, Meyniel L, Delmotte S, Gautier C, Andr\E9 P, Lotteau V, Rabourdin-Combe C. VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks. Nucleic Acids Res. 2009 Jan;37(Database issue):D661-8. Epub 2008 Nov 4. PubMed PMID: 18984613; PubMed Central PMCID: PMC2686459.
5 VirusMINT
A database of viral-host protein interactions. Provides option to build interactomes.
Chatr-aryamontri A, Ceol A, Peluso D, Nardozza A, Panni S, Sacco F, Tinti M, Smolyar A, Castagnoli L, Vidal M, Cusick ME, Cesareni G. VirusMINT: a viral protein interaction database. Nucleic Acids Res. 2009 Jan;37(Database issue):D669-73. Epub 2008 Oct 30. PubMed PMID: 18974184; PubMed Central PMCID: PMC2686573.
copyright © Dr. Kshitish Acharya K; all rights reserved

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