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A comparative account of protein-protein interaction resources, feature-validations and application-based categorizations : PPIs for a specific disease
S.NoResources Important features / utilities*CitationsYear of publicationRank by usage frequency Click to Edit / Add comments
1 IntAct
A database that provides protein-protein interactions of experimental importance. Protein-protein interactions for few specific diseases are available. Protein interactions specific to a biological process (e.g., apoptosis, cell cycle) can also be obtained. Provides interactions along with their functional associations. Interactions can be restricted to a given experimental evidence. Provides interactions related to cancer. Provides protein-drug interactions. User interaface parameters can be implied to the input.
Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A, Margalit H, Armstrong J, Bairoch A, Cesareni G, Sherman D, Apweiler R. IntAct: an open source molecular interaction database. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D452-5. PubMed PMID: 14681455; PubMed Central PMCID: PMC308786.
2 BIND/BOND - Biomolecular Object Network Databank
A database of protein-domain/ domain-domain interactions. Provides PPIs for a specific disease (e.g., prostate cancer). Provides protein-small molecule, protein-nucleic acid & genetic interactions. Provides the interactions along with the complexes and pathways involved. Also provides viral-human protein interactions (e.g., HIV-host protein interactions).
Bader GD, Donaldson I, Wolting C, Ouellette BF, Pawson T, Hogue CW. BIND--The Biomolecular Interaction Network Database. Nucleic Acids Res. 2001 Jan 1;29(1):242-5. PubMed PMID: 11125103; PubMed Central PMCID: PMC29820.
3 MIPS-MPPI - MIPS Mammalian Protein-Protein Interaction
A web-resource specific to mammalian PPIs. Provides interactions for a specific disease/biological process. Provides interactions along with their functional associations. Interactions can be restricted to a specific experimental evidence.
Pagel P, Kovac S, Oesterheld M, Brauner B, Dunger-Kaltenbach I, Frishman G, Montrone C, Mark P, StFCmpflen V, Mewes HW, Ruepp A, Frishman D. The MIPS mammalian protein-protein interaction database. Bioinformatics. 2005 Mar;21(6):832-4. Epub 2004 Nov 5. PubMed PMID: 15531608
copyright © Dr. Kshitish Acharya K; all rights reserved

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