1 |
CONTRAST - CONditionally TRAined Search for Transcriptshttp://contra.stanford.edu/contrast/ |
Predicts protein-coding genes from a multiple genomic alignment. It is designed for de novo predictions. It can also incorporate information from EST alignments. |
| Gross SS, Do CB, Sirota M, Batzoglou S. CONTRAST: a discriminative, phylogeny-free approach to multiple informant de novo gene prediction. Genome Biol. 2007;8(12):R269. PubMed PMID: 18096039; PubMed Central PMCID: PMC2246271.
|
| 2007 | 1 |
Predicitions downloadable or can be browsed by using UCSC genome browser. Predicitions downloadable or can be browsed by using UCSC genome browser. |
2 |
BDGP - Berkeley Drosophila Genome Projecthttp://www.fruitfly.org/seq_tools/splice.html |
Used to predict the splite sites with the help of neural networks. It shows the intron/exon boundary as well. |
| Spradling AC, Stern D, Beaton A, Rhem EJ, Laverty T, Mozden N, Misra S, Rubin GM. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics. 1999
Sep;153(1):135-77. PubMed PMID: 10471706; PubMed Central PMCID: PMC1460730.
|
| 1999 | 50 |
1) Splice Site details include start position, end position and score for acceptor as well as donor sites. 2) The exon/Intron boundary is shown by enlarging the font size. 1) Splice Site details include start position, end position and score for acceptor as well as donor sites. 2) The exon/Intron boundary is shown by enlarging the font size. |
3 |
ECgenehttp://genome.ewha.ac.kr/ECgene |
| Lee Y, Lee Y, Kim B, Shin Y, Nam S, Kim P, Kim N, Chung WH, Kim J, Lee S.
ECgene: an alternative splicing database update. Nucleic AcIDs Res. 2007
Jan;35(Database issue):D99-103. Epub 2006 Nov 28. PubMed PMID: 17132829; PubMed
Central PMCID: PMC1716719.
|
| 2006 | 98 |
URL working but not leading to any result page after the query has been given. URL working but not leading to any result page after the query has been given. |
4 |
Augustushttp://augustus.gobics.de/submission |
| Stanke M, Keller O, Gunduz I, Hayes A, Waack S, Morgenstern B. AUGUSTUS: ab initio prediction of alternative transcripts. Nucleic AcIDs Res. 2006 Jul 1;34(Web Server issue):W435-9. PubMed PMID: 16845043; PubMed Central PMCID:
PMC1538822.
|
| 2006 | 99 |
1) This method allows approximation of the true intron length distribution more accurately than do existing programs. 2) It gives alignment results.These can be downloaded as well. 3) Gives predicted coding sequences. 1) This method allows approximation of the true intron length distribution more accurately than do existing programs. 2) It gives alignment results.These can be downloaded as well. 3) Gives predicted coding sequences. |
5 |
BLAT - BLAST like Alignment toolhttp://genome.ucsc.edu/cgi-bin/hgBlat?command=start |
| Kent WJ. BLAT--the BLAST-like alignment tool. Genome Res. 2002
Apr;12(4):656-64. PubMed PMID: 11932250; PubMed Central PMCID: PMC187518.
|
| 2002 | 99 |
1) Link to UCSC Genome browser is given. 2) Splice Sites are marked in the sequence itself, with light blue colour. 1) Link to UCSC Genome browser is given. 2) Splice Sites are marked in the sequence itself, with light blue colour. |
6 |
C-Ithttp://C-It.mpi-bn.mpg.de |
| Gellert P, Jenniches K, Braun T, UchIDa S. C-It: a knowledge database for tissue-enriched genes. Bioinformatics. 2010 Sep 15;26(18):2328-33. Epub 2010 Jul
13. PubMed PMID: 20628071.
|
| 2010 | 99 |
1) Search results downloadable. 2) Gives links to all the pubmed articles mentioning the queried gene 1) Search results downloadable. 2) Gives links to all the pubmed articles mentioning the queried gene |
7 |
ACEScanhttp://genes.mit.edu/acescan/ |
Provides ACEScan score for orthologous human-mouse exons. |
| | Not available | 100 |
Gives graphical representation of all ACEScan scored exons. Gives graphical representation of all ACEScan scored exons. |
8 |
AceViewhttp://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/index.html |
| Thierry-Mieg D, Thierry-Mieg J. AceView: a comprehensive cDNA-supported gene
and transcripts annotation. Genome Biol. 2006;7 Suppl 1:S12.1-14. Epub 2006 Aug
7. PubMed PMID: 16925834; PubMed Central PMCID: PMC1810549.
|
| 2006 | 100 |
Compact Gene diagram is shown as an output, which marks the exon length. Number of cDNA's supporting each intron, good proteins, partial or not good proteins are also marked. Compact Gene diagram is shown as an output, which marks the exon length. Number of cDNA's supporting each intron, good proteins, partial or not good proteins are also marked. |
9 |
Agenehttp://servers.binf.ku.dk/agene/ |
| Munch K, Krogh A. Automatic generation of gene finders for eukaryotic species.
BMC Bioinformatics. 2006 May 21;7:263. PubMed PMID: 16712739; PubMed Central
PMCID: PMC1522026.
|
| 2006 | 100 |
1) Requires registration. 2) Returns error "Please note that this software is no longer being supported or updated." as on 26th july 2012 3) GeneMachine is available by anonymous FTP at ftp://ftp.nhgri.nih.gov/pub/software/genemachine/. "1) Requires registration. 2) Returns error ""Please note that this software is no longer being supported or updated."" as on 26th july 2012 3) GeneMachine is available by anonymous FTP at ftp://ftp.nhgri.nih.gov/pub/software/genemachine/." |
10 |
AS-ALPS - Alternative Splicing Induced Alteration of Protein Structurehttp://as-alps.nagahama-i-bio.ac.jp/ |
| Shionyu M, Yamaguchi A, Shinoda K, Takahashi K, Go M. AS-ALPS: a database for
analyzing the effects of alternative splicing on protein structure, interaction
and network in human and mouse. Nucleic AcIDs Res. 2009 Jan;37(Database
issue):D305-9. Epub 2008 Nov 10. PubMed PMID: 19015123; PubMed Central PMCID:
PMC2686549.
|
| 2009 | 100 |
1) Alternative Splicing type and position is given. 2) Uninformative transcripts can also be seen. 3) Splice site details include the position of the Alternative spliced region. 1) Alternative Splicing type and position is given. 2) Uninformative transcripts can also be seen. 3) Splice site details include the position of the Alternative spliced region. |
11 |
ASAP II - Alternative Splicing Annotation Projecthttp://bioinfo.mbi.ucla.edu/ASAP2/ |
| Kim N, Alekseyenko AV, Roy M, Lee C. The ASAP II database: analysis and
comparative genomics of alternative splicing in 15 animal species. Nucleic AcIDs
Res. 2007 Jan;35(Database issue):D93-8. Epub 2006 Nov 15. PubMed PMID: 17108355;
PubMed Central PMCID: PMC1669709.
|
| 2006 | 100 |
1) Gives Genomic expression. 2) Gives Genomic location, gene aliases etc. as gene information. 3) Orthologous genes identified by MULTIZ alignments are given. 4) Isoform sequences are given. 5) Type of exons- Alternative or Constitute are given along with genomic position and number of EST and mRNA observed. 6) Intron type- Alternative or Constitutive, 5 site, 3 site, whether canonical or not and splice type, all information is provided. 7) Alternative Splicing information is provided. 1) Gives Genomic expression. 2) Gives Genomic location, gene aliases etc. as gene information. 3) Orthologous genes identified by MULTIZ alignments are given. 4) Isoform sequences are given. 5) Type of exons- Alternative or Constitute are given along with genomic position and number of EST and mRNA observed. 6) Intron type- Alternative or Constitutive, 5 site, 3 site, whether canonical or not and splice type, all information is provided. 7) Alternative Splicing information is provided. |
12 |
asg - Alternative Splicing Galleryhttp://statgen.ncsu.edu/asg/ |
It integrates transcript information into splicing graphs in order to visualize gene structure and alternative splicing. |
| Leipzig J, Pevzner P, Heber S. The Alternative Splicing Gallery (ASG): brIDging the gap between genome and transcriptome. Nucleic AcIDs Res. 2004 Aug 3;32(13):3977-83. Print 2004. PubMed PMID: 15292448; PubMed Central PMCID:PMC506815. |
| 2004 | 100 |
Gene information includes chromosome number, start and end position, strand information. Gene information includes chromosome number, start and end position, strand information. |
13 |
ASPic - Alternative Splicing Predictionhttp://t.caspur.it/ASPIC/index.php |
1) Detect the exon-intron structure of a gene. 2) Predicts constitutive and alternative splice sites. |
| Bonizzoni P, Rizzi R, Pesole G. ASPIC: a novel method to predict the exon-intron structure of a gene that is optimally compatible to a set of transcript sequences. BMC Bioinformatics. 2005 Oct 5;6:244. PubMed PMID:16207377; PubMed Central PMCID: PMC1276783. |
| 2005 | 100 |
1) Requires registration. 2) Gene name Brca1 and mybl2 as well as uploaded sequence didn't receive any results when used in the option of 'RUN Aspic'. 3) Provides option of retrieving Unigene ID for input. 4) Results are obtained in E-mail. 5) Gives genomic and transcript sequences. 6) Gene structure view is provided, showing Refseq exon, Novel exon, Refseq Intron, Novel intron, Fuzzy Intron, Canonical splice site and Non-Canonical splice site. 7) Shows 3'UTR and 5'UTR, Poly A site 8) Splice site details include the intron number, chromosome number, length, donor/ acceptor score, branching site score 9) Intron table provides information about relative and absolute start as well as relative and absolute end of intron, number of EST's, chromosome number, intron class, and Donor and acceptor site. 9) Gene information includes chromosome number, strand, position and length of gene. 1) Requires registration. 2) Gene name Brca1 and mybl2 as well as uploaded sequence didn't receive any results when used in the option of 'RUN Aspic'. 3) Provides option of retrieving Unigene ID for input. 4) Results are obtained in E-mail. 5) Gives genomic and transcript sequences. 6) Gene structure view is provided, showing Refseq exon, Novel exon, Refseq Intron, Novel intron, Fuzzy Intron, Canonical splice site and Non-Canonical splice site. 7) Shows 3'UTR and 5'UTR, Poly A site 8) Splice si |
14 |
ASPicDB - Alterenative Splicing Prediction databasehttp://t.caspur.it/ASPicDB/ |
| CastrignanF2 T, D'Antonio M, Anselmo A, Carrabino D, D'Onorio De Meo A,
D'Erchia AM, Licciulli F, Mangiulli M, Mignone F, Pavesi G, Picardi E, Riva A, Rizzi R, Bonizzoni P, Pesole G. ASPicDB: a database resource for alternative splicing analysis. Bioinformatics. 2008 May 15;24(10):1300-4. Epub 2008 Apr 3. PubMed PMID: 18388144. |
| 2008 | 100 |
|
15 |
ASRG - ArabidopsisSplicing Related Geneshttp://www.plantgdb.org/prj/SiP/SRGD/ASRG |
| Wang BB, Brendel V. The ASRG database: identification and survey of
Arabidopsis thaliana genes involved in pre-mRNA splicing. Genome Biol. 2004;5(12):R102. Epub 2004 Nov 29. PubMed PMID: 15575968; PubMed Central PMCID:PMC545797.
|
| 2004 | 100 |
1) Didn't return any results using search fields when tried multiple times. 2) Browsing results not displayed properly due to some error in page. 1) Didn't return any results using search fields when tried multiple times. 2) Browsing results not displayed properly due to some error in page. |
16 |
Astalavista - Alternative splicing transcriptional landscape visualization toolhttp://genome.crg.es/astalavista/ |
Identifies complex Alternative Splice events by comparing all given transcripts. |
| Foissac S, Sammeth M. ASTALAVISTA: dynamic and flexible analysis of alternative splicing events in custom gene datasets. Nucleic AcIDs Res. 2007 Jul;35(Web Server issue):W297-9. Epub 2007 May 7. PubMed PMID: 17485470; PubMed
Central PMCID: PMC1933205.
|
| 2007 | 100 |
1) The results can be browsed on UCSC browser. 2)Results can be downloaded in GTF or ASTA format. 3) Splice site details include the chromosome number, and the position of Alternative Splice sites. 4) Intron- Exon structure is also shown. 5) Types of Alternative Splice Events include exon skipping, alt acceptor and intron retention. 1) The results can be browsed on UCSC browser. 2)Results can be downloaded in GTF or ASTA format. 3) Splice site details include the chromosome number, and the position of Alternative Splice sites. 4) Intron- Exon structure is also shown. 5) Types of Alternative Splice Events include exon skipping, alt acceptor and intron retention. |
17 |
ASTRA - Alternative Splicing and TRanscription Archiveshttp://alterna.cbrc.jp/ |
Database for identification of patterns of alternative splicing and transcriptional initiation. Exons introns structures of splice variants can be viewed on java applet. |
| Not available | Not available | 100 |
1) Gene information includes Gene name, chromosome number, strand, position and number of patterns. 2) Sequence of gene can be downloaded. 3) Data of Alternative Splicing can also be downloaded. 1) Gene information includes Gene name, chromosome number, strand, position and number of patterns. 2) Sequence of gene can be downloaded. 3) Data of Alternative Splicing can also be downloaded. |
18 |
AVATARhttp://avatar.iecs.fcu.edu.tw/ |
| Hsu FR, Chang HY, Lin YL, Tsai YT, Peng HL, Chen YT, Cheng CY, Shih MY, Liu
CH, Chen CF. AVATAR: a database for genome-wIDe alternative splicing event
detection using large scale ESTs and mRNAs. Bioinformation. 2005 Apr
22;1(1):16-8. PubMed PMID: 17597845; PubMed Central PMCID: PMC1891626. |
| 2005 | 100 |
URL not working as on 14 Dec 2012 URL not working as on 14 Dec 2012 |
19 |
BIPASS - Bioinformatics Pipeline Alternative Splicing Serviceshttp://bip.umiacs.umd.edu:8080/ |
| Lacroix Z, Legendre C, RaschID L, Snyder B. BIPASS: BioInformatics Pipeline
Alternative Splicing Services. Nucleic AcIDs Res. 2007 Jul;35(Web Server
issue):W292-6. Epub 2007 Jun 21. PubMed PMID: 17584795; PubMed Central PMCID:
PMC1933140. |
| 2007 | 100 |
URL not working as on 14 Dec 2012 URL not working as on 14 Dec 2012 |
20 |
ChimerDBhttp://genome.ewha.ac.kr/ChimerDB/ |
| Kim N, Kim P, Nam S, Shin S, Lee S. ChimerDB--a knowledgebase for fusion
sequences. Nucleic AcIDs Res. 2006 Jan 1;34(Database issue):D21-4. PubMed PMID:
16381848; PubMed Central PMCID: PMC1347382.
|
| 2006 | 100 |
Url working, but gives error in result page as on 27th July 2012 Url working, but gives error in result page as on 27th July 2012 |
21 |
EDAS - EST Derived Alternative Splicinghttp://edas2.bioinf.fbb.msu.ru/ |
EDAS, a database of alternatively spliced human genes, contains data on the alignment of proteins, mRNAs, and EST. It contains information on all exons and introns observed, as well as elementary alternatives formed from them. |
| Nurtdinov RN, Neverov AD, Mal'ko DB, Kosmodem'ianskii IA, Ermakova EO,
Ramenskii VE, Mironov AA, Gel'fand MS. [EDAS, databases of alternatively spliced human genes]. Biofizika. 2006 Jul-Aug;51(4):589-92. Russian. PubMed PMID:
16909834. |
| 2006 | 100 |
|
22 |
EuSplicehttp://sege.ntu.edu.sg/wester/ashes/ |
Identifies the alternative splicing by exon skipping. |
| Bhasi A, Pandey RV, Utharasamy SP, Senapathy P. EuSplice: a unified resource for the analysis of splice signals and alternative splicing in eukaryotic genes. Bioinformatics. 2007 Jul 15;23(14):1815-23. Epub 2007 Mar 7. PubMed PMID:17344236. |
| 2005 | 100 |
URL not working as on 14 Dec 2012 URL not working as on 14 Dec 2012 |
23 |
FESD - Functional Element SNP's Databasehttp://combio.kribb.re.kr/ksnp/resd/. |
| Kang HJ, Choi KO, Kim BD, Kim S, Kim YJ. FESD: a Functional Element SNPs Database in human. Nucleic AcIDs Res. 2005 Jan 1;33(Database issue):D518-22.
Erratum in: Nucleic AcIDs Res. 2005;33(1):449. PubMed PMID: 15608252; PubMed
Central PMCID: PMC540036. |
| 2005 | 100 |
URL not working as on 30th july 2012 URL not working as on 30th july 2012 |
24 |
FirstEF - First Exon Finderhttp://rulai.cshl.edu/tools/FirstEF/ |
Identifies the first exon, i.e, 5' terminal exon and promoter. It also gives the rank of the first exon within the cluster. |
| Davuluri RV. Application of FirstEF to find promoters and first exons in the human genome. Curr Protoc Bioinformatics. 2003 May;Chapter 4:Unit4.7. PubMed PMID: 18428702. |
| 2003 | 100 |
1) Gives predictions on direct as well as complementary strand. 2) Gives serial number of predicted exon cluster. 3) Gives predicted Promoter of length 570 bp. 4) Gives a posteriori probability of promoter for a given window of 570 bp. 5) Gives posteriori probablity of exon for a given GT and promoter region. 6) Gives posteriori probability of donor for a given GT. 7)Gives Boundaries of CpG window of length 201. 8) Gives rank of first exon within a cluster. 9) Results can be obtained by e-mail. 1) Gives predictions on direct as well as complementary strand. 2) Gives serial number of predicted exon cluster. 3) Gives predicted Promoter of length 570 bp. 4) Gives a posteriori probability of promoter for a given window of 570 bp. 5) Gives posteriori probablity of exon for a given GT and promoter region. 6) Gives posteriori probability of donor for a given GT. 7)Gives Boundaries of CpG window of length 201. 8) Gives rank of first exon within a cluster. 9) Results can be obtained by e-mail. |
25 |
GatExplorer - Genomic and Transcriptomic Explorerhttp://bioinfow.dep.usal.es/xgate/principal.php |
GATExplorer is an integrated database that combines genomic/transcriptomic visualization with nucleotide-level probe mapping. |
| RisueF1o A, Fontanillo C, Dinger ME, De Las Rivas J. GATExplorer: genomic and transcriptomic explorer; mapping expression probes to gene loci, transcripts,
exons and ncRNAs. BMC Bioinformatics. 2010 Apr 29;11:221. PubMed PMID: 20429936;
PubMed Central PMCID: PMC2875241.
|
| 2010 | 100 |
Gene information includes chromosome location and gene description. Gene information includes chromosome location and gene description. |
26 |
GeneBuilderhttp://zeus2.itb.cnr.it/~webgene/genebuilder.html |
1) Predicts TATA box(i.e, TATA box pattern and position) and Poly-A site prediction(i.e, position and pattern). 2) Gives view of transcription factors. |
| Milanesi L, D'Angelo D, Rogozin IB. GeneBuilder: interactive in silico prediction of gene structure. Bioinformatics. 1999 Jul-Aug;15(7-8):612-21. PubMed PMID: 10487869. |
| 1999 | 100 |
Gene model and Coding potential are shown graphically, but are not loading as on 25th july 2012 Gene model and Coding potential are shown graphically, but are not loading as on 25th july 2012 |
27 |
GeneCardshttp://www.genecards.org/ |
It is a kind of search engine and gives visualization of gene expression patterns in normal and cancer tissues, integrated alternative splicing pattern display. It also displays SNP's. |
| Safran M, Dalah I, Alexander J, Rosen N, Iny Stein T, Shmoish M, Nativ N,
Bahir I, Doniger T, Krug H, Sirota-Madi A, Olender T, Golan Y, Stelzer G, Harel
A, Lancet D. GeneCards Version 3: the human gene integrator. Database (Oxford).
2010 Aug 5;2010:baq020. PubMed PMID: 20689021; PubMed Central PMCID: PMC2938269.
|
| 2010 | 100 |
Disorders/ Disease information is also provided.One can know the Function, Genomic View, Orthologs and paralogs for a particular gene. Along with this, Pathway information, domain and family information is displayed Disorders/ Disease information is also provided.One can know the Function, Genomic View, Orthologs and paralogs for a particular gene. Along with this, Pathway information, domain and family information is displayed |
28 |
GeneMarkhttp://exon.biology.gatech.edu/eukhmm.cgi#prot |
| Borodovsky M, Lomsadze A, Ivanov N, Mills R. Eukaryotic gene prediction using GeneMark.hmm. Curr Protoc Bioinformatics. 2003 May;Chapter 4:Unit4.6. PubMed
PMID: 18428701.
|
| 2003 | 100 |
1) Results can be obtained by e-mail. 2) Gene information includes the Gene number and strand type. 3) Frame information is also given. 1) Results can be obtained by e-mail. 2) Gene information includes the Gene number and strand type. 3) Frame information is also given. |
29 |
GeneNesthttp://genenest.molgen.mpg.de/ |
GeneNest is a comprehensive visualization of gene indices of the organisms. The aim of GeneNest is to represent each gene by a single cluster of ESTs and/or mRNAs. |
| Haas SA, Beissbarth T, Rivals E, Krause A, Vingron M. GeneNest: automated generation and visualization of gene indices. Trends Genet. 2000
Nov;16(11):521-3. PubMed PMID: 12199289.
|
| 2000 | 100 |
|
30 |
GeneSeqerhttp://deepc2.psi.iastate.edu/cgi-bin/gs.cgi |
Identify potential exon/intron structure in pre-mRNA by splice site prediction and spliced alignment. |
| Brendel V, Xing L, Zhu W. Gene structure prediction from consensus spliced alignment of multiple ESTs matching the same genomic locus. Bioinformatics. 2004 May 1;20(7):1157-69. Epub 2004 Feb 5. PubMed PMID: 14764557. |
| 2004 | 100 |
1) Looks for the EST matches. 2) E-mail notification. 3) Specialized GeneSeqer server at PlantGDB is used to align plant sequences. 1) Looks for the EST matches. 2) E-mail notification. 3) Specialized GeneSeqer server at PlantGDB is used to align plant sequences. |
31 |
GeneSplicerhttp://cbcb.umd.edu/software/GeneSplicer/gene_spl.shtml |
| | Not available | 100 |
1) Results can be obtained by E-mail. 2) Returns an error "Use of uninitialized value in string eq at /export/www/cgi-bin/cbcb/genesplicer/gspl_cgi.cgi line 162, line 162." after multiple tries "1) Results can be obtained by E-mail. 2) Returns an error ""Use of uninitialized value in string eq at /export/www/cgi-bin/cbcb/genesplicer/gspl_cgi.cgi line 162, line 162."" after multiple tries" |
32 |
GenomeThreaderhttp://www.plantgdb.org/cgi-bin/GenomeThreader/gth.cgi |
The GenomeThreader server allows you to perform spliced alignment of protein or EST/cDNA sequences to genomic DNA. |
| | Not available | 100 |
|
33 |
GenView 2http://zeus2.itb.cnr.it/~webgene/wwwgene.html |
| Ronneberg TA, Freeland SJ, Landweber LF. Genview and Gencode : a pair of programs to test theories of genetic code evolution. Bioinformatics. 2001
Mar;17(3):280-1. PubMed PMID: 11294793.
|
| 2001 | 100 |
1) Results can be mailed to the user as per his/her choice. 2) The result page is not returning any results except the sequence and the translated peptide sequence that has been submitted as on25-july-2012 1) Results can be mailed to the user as per his/her choice. 2) The result page is not returning any results except the sequence and the translated peptide sequence that has been submitted as on25-july-2012 |
34 |
GOOD - Gene Oriented Ortholog Databsehttp://goods.ibms.sinica.edu.tw/goods/index.html |
| Ho MR, Chen CH, Lin WC. Gene-oriented ortholog database: a functional comparison platform for orthologous loci. Database (Oxford). 2010;2010:baq002.
Epub 2010 Feb 10. PubMed PMID: 20428317; PubMed Central PMCID: PMC2860896. |
| 2010 | 100 |
1) Gives chromosome number and strand information as gene information. 2) Only the number of transcripts are given,which are linked to homologene (ncbi). 3) Also annotations from gene ontology are mentioned (molecular function, biological process, cellular component). 4) Reference transcripts, processed transcription units, orthologous tables, gene ontology can be downloaded. 5) Gives the detail of the different transcripts pertaining to that gene. 1) Gives chromosome number and strand information as gene information. 2) Only the number of transcripts are given,which are linked to homologene (ncbi). 3) Also annotations from gene ontology are mentioned (molecular function, biological process, cellular component). 4) Reference transcripts, processed transcription units, orthologous tables, gene ontology can be downloaded. 5) Gives the detail of the different trans |
35 |
GRSDB - 'G' Rich Sequences Databasehttp://bioinformatics.ramapo.edu/grsdb/index.php |
Offers a visual comparison of G-quadruplex distribution patterns among all the alternative RNA products of a gene with the help of dynamic graphics. |
| Kostadinov R, Malhotra N, Viotti M, Shine R, D'Antonio L, Bagga P. GRSDB: a database of quadruplex forming G-rich sequences in alternatively processed
mammalian pre-mRNA sequences. Nucleic AcIDs Res. 2006 Jan 1;34(Database
issue):D119-24. PubMed PMID: 16381828; PubMed Central PMCID: PMC1347436.
|
| 2006 | 100 |
1) QGRS(Quadruplex forming 'G'-Rich Sequences) sequence is given. 1) QGRS(Quadruplex forming 'G'-Rich Sequences) sequence is given. |
36 |
H-DBAS - Human Transcriptome Database for Alternative Splicinghttp://jbirc.jbic.or.jp/h-dbas/ |
| Takeda J, Suzuki Y, Sakate R, Sato Y, Gojobori T, Imanishi T, Sugano S.
H-DBAS: human-transcriptome database for alternative splicing: update 2010. Nucleic AcIDs Res. 2010 Jan;38(Database issue):D86-90. Epub 2009 Dec 7. PubMed PMID: 19969536; PubMed Central PMCID: PMC2808982. |
| 2010 | 100 |
1) Gene information gives chromosome number, position and strand. 2) Results can be downloaded. 3) Splice site details are shown graphically. 4) Also shows SNP in the graph. 5) Gene expression information is given, giving tissue specific expression in Affymetrix gene chip and Agilent. 6) Also gives information about Transcript feature. 1) Gene information gives chromosome number, position and strand. 2) Results can be downloaded. 3) Splice site details are shown graphically. 4) Also shows SNP in the graph. 5) Gene expression information is given, giving tissue specific expression in Affymetrix gene chip and Agilent. 6) Also gives information about Transcript feature. |
37 |
HMMGenehttp://www.cbs.dtu.dk/services/HMMgene/ |
HMMgene is a program for prediction of genes in anonymous DNA. It can also be used to predict splice sites and start/stop codons. If some features of a sequence are known, such as hits to ESTs, proteins, or repeat elements, these regions can be locked as coding or non-coding, and then the program will find the best gene structure under these constraints. |
| Krogh A. Using database matches with for HMMGene for automated gene detection in Drosophila. Genome Res. 2000 Apr;10(4):523-8. PubMed PMID: 10779492; PubMed
Central PMCID: PMC310864.
|
| 2000 | 100 |
1) Score (0 or 1), strand and Frame information is also given. 2) Predicted donor and acceptor site with position of base before and after splice site is given. 1) Score (0 or 1), strand and Frame information is also given. 2) Predicted donor and acceptor site with position of base before and after splice site is given. |
38 |
Hollywoodhttp://hollywood.mit.edu/hollywood/Login.php |
| Holste D, Huo G, Tung V, Burge CB. HOLLYWOOD: a comparative relational database of alternative splicing. Nucleic AcIDs Res. 2006 Jan 1;34(Database
issue):D56-62. PubMed PMID: 16381932; PubMed Central PMCID: PMC1347411.
|
| 2006 | 100 |
Requires login,but no option to make a new account, so as to login and use the database. Requires login,but no option to make a new account, so as to login and use the database. |
39 |
HS3D - Homo sapiens Splice Site Datasethttp://www.sci.unisannio.it/docenti/rampone/ |
HS3D (Homo Sapiens Splice Sites Dataset) is a data set of Homo sapiens Exon, Intron and Splice regions extracted from GenBank Rel.123. |
| Pasquale Pollastro and Salvatore Rampone. HS3D, a dataset of Homo sapiens splice regions, and its extraction procedure from a major public database.
Int. J. Mod. Phys. C 13, 1105 (2002). |
| Not available | 100 |
1) Result is only downloadable. No search option is provided. 2) Intron-Exon true splice sites extracted from filtered Genbank and Intron- exon false splice sites extracted from genbank are downloadable in Zip format. 1) Result is only downloadable. No search option is provided. 2) Intron-Exon true splice sites extracted from filtered Genbank and Intron- exon false splice sites extracted from genbank are downloadable in Zip format. |
40 |
MAASE - Manually Annotated Alternatively Spliced Eventshttp://xmaase.genomics.purdue.edu/ |
It is a resource for convenient access, identification, and annotation of alternative splicing events (ASEs). |
| Zheng CL, Kwon YS, Li HR, Zhang K, Coutinho-Mansfield G, Yang C, Nair TM,
Gribskov M, Fu XD. MAASE: an alternative splicing database designed for supporting splicing microarray applications. RNA. 2005 Dec;11(12):1767-76. Epub
2005 Oct 26. PubMed PMID: 16251387; PubMed Central PMCID: PMC1370865.
|
| 2005 | 100 |
Returns error "Please specify a search term." after putting in the query term " Returns error ""Please specify a search term."" after putting in the query term " |
41 |
MZEF - Michael Zhang's Exon Finderhttp://rulai.cshl.edu/tools/genefinder/ |
Predict putative internal protein coding exons in genomic DNA sequences. |
| Zhang MQ. Using MZEF to find internal coding exons. Curr Protoc
Bioinformatics. 2002 Aug;Chapter 4:Unit 4.2. Review. PubMed PMID: 18792940. |
| 2002 | 100 |
1) Gives the posterior probability. 2) Gives Frame preference score for ith frame. 3) Gives acceptor and donor score in splice site details. 4) Gives coding preference score. 5) Results can be obtained in E-mail. 1) Gives the posterior probability. 2) Gives Frame preference score for ith frame. 3) Gives acceptor and donor score in splice site details. 4) Gives coding preference score. 5) Results can be obtained in E-mail. |
42 |
PALS Db - Putative Alternative Splicing Databaseshttp://palsdb.ym.edu.tw/ |
| Huang YH, Chen YT, Lai JJ, Yang ST, Yang UC. PALS db: Putative Alternative Splicing database. Nucleic AcIDs Res. 2002 Jan 1;30(1):186-90. PubMed PMID:
11752289; PubMed Central PMCID: PMC99163. |
| 2002 | 100 |
URL not working as on14 Dec 2012 URL not working as on14 Dec 2012 |
43 |
PolyA_DBhttp://polya.umdnj.edu/polyadb |
It specializes in identification of Poly-A tail. |
| Zhang H, Hu J, Recce M, Tian B. PolyA_DB: a database for mammalian mRNA polyadenylation. Nucleic AcIDs Res. 2005 Jan 1;33(Database issue):D116-20. PubMed
PMID: 15608159; PubMed Central PMCID: PMC540009.
|
| 2005 | 100 |
URL not working as on 14 Dec 2012 URL not working as on 14 Dec 2012 |
44 |
PolyA_DB 2http://polya.umdnj.edu/PolyA_DB2 |
It specializes in identification of Poly-A tail. |
| Lee JY, Yeh I, Park JY, Tian B. PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes. Nucleic AcIDs Res. 2007 Jan;35(Database issue):D165-8. PubMed PMID: 17202160; PubMed Central PMCID: PMC1899096. |
| 2007 | 100 |
URL not working as on 14 Dec 2012 URL not working as on 14 Dec 2012 |
45 |
ProSAShttp://services.bio.ifi.lmu.de/ProSAS/ |
| Birzele F, KFCffner R, Meier F, Oefinger F, Potthast C, Zimmer R. ProSAS: a database for analyzing alternative splicing in the context of protein structures.
Nucleic AcIDs Res. 2008 Jan;36(Database issue):D63-8. Epub 2007 Oct 11. PubMed
PMID: 17933774; PubMed Central PMCID: PMC2238869. |
| 2008 | 100 |
1) Gene information includes chromosome number and strand information. 2) Returning database error as on 28th july 2012 1) Gene information includes chromosome number and strand information. 2) Returning database error as on 28th july 2012 |
46 |
Rescue-ESEhttp://genes.mit.edu/burgelab/rescue-ese/ |
| Fairbrother WG, Yeo GW, Yeh R, Goldstein P, Mawson M, Sharp PA, Burge CB. RESCUE-ESE IDentifies candIDate exonic splicing enhancers in vertebrate exons. Nucleic AcIDs Res. 2004 Jul 1;32(Web Server issue):W187-90. PubMed PMID:
15215377; PubMed Central PMCID: PMC441531.
|
| 2004 | 100 |
Gives Exonic Splicing Enhancer motifs. Gives Exonic Splicing Enhancer motifs. |
47 |
RNAdb - RNA Databasehttp://research.imb.uq.edu.au/rnadb/default.aspx |
It is a comprehensive mammalian non-coding RNA database, which contains the sequences and annotations of non- coding RNAs. |
| Pang KC, Stephen S, EngstrF6m PG, Tajul-Arifin K, Chen W, Wahlestedt C, Lenhard
B, Hayashizaki Y, Mattick JS. RNAdb--a comprehensive mammalian noncoding RNA
database. Nucleic AcIDs Res. 2005 Jan 1;33(Database issue):D125-30. PubMed PMID:
15608161; PubMed Central PMCID: PMC540043.
|
| 2005 | 100 |
URL not working as on 14 Dec 2012 URL not working as on 14 Dec 2012 |
48 |
Softberryhttp://linux1.softberry.com/berry.phtml |
1) Pattern based human gene structure prediction (multiple genes, both chains). 2) Find splice sites in genomic DNA using weight matrices. 3) BESTORF program analyses EST/mRNA sequences to predict potential coding fragments. 4) FGENE-SH is human gene prediction that allows to predict genes containing minor variants of donor splice sites (GC sites). 5) Looks for Pattern-based human multiple variants (alternative splicing) of potential genes in genomic DNA. 6) Finding potential 5'-, internal and 3'-coding exons. 7) Rna SPL is used for For exon-exon junctions positions in human cDNA. |
| | Not available | 100 |
|
49 |
SpliceCenterhttp://projects.insilico.us/SpliceCenter/SpliceOverview.jsp |
1)Displays gene splice variants and probe target locations for expression microarray platforms.A0 2)Provides a summary of splice variant coverage of multiple genes for common microarray platforms. A03)Provides high-througput analysis of peptide sequences indicating the splice variants that do / do not include the peptide.A0 |
| Ryan MC, Zeeberg BR, Caplen NJ, Cleland JA, Kahn AB, Liu H, Weinstein JN. SpliceCenter: a suite of web-based bioinformatic applications for evaluating the
impact of alternative splicing on RT-PCR, RNAi, microarray, and peptIDe-based studies. BMC Bioinformatics. 2008 Jul 18;9:313. PubMed PMID: 18638396; PubMed Central PMCID: PMC2491637.
|
| 2008 | 100 |
1) Gene information includes the chromosome number, strand, start, stop. 2) Peptide check displays the coding sequence for a peptide within splice variant of a gene. 3) Expression- check provides visualization of microarray expression data for a gene 4) Batch tools are also provided. 1) Gene information includes the chromosome number, strand, start, stop. 2) Peptide check displays the coding sequence for a peptide within splice variant of a gene. 3) Expression- check provides visualization of microarray expression data for a gene 4) Batch tools are also provided. |
50 |
SpliceDB - Splice Databasehttp://www.softberry.com/spldb/SpliceDB.html |
| Burset M, Seledtsov IA, Solovyev VV. SpliceDB: database of canonical and non-canonical mammalian splice sites. Nucleic AcIDs Res. 2001 Jan 1;29(1):255-9.
PubMed PMID: 11125105; PubMed Central PMCID: PMC29840. |
| 2001 | 100 |
|
51 |
SpliceIThttp://www.med.auth.gr/research/spliceIT |
It is is a hybrid method for splice site prediction based on probabilistic and biological inference. |
| Malousi A, Chouvarda I, Koutkias V, KouIDou S, Maglaveras N. SpliceIT: a
hybrID method for splice signal identification based on probabilistic and biological inference. J Biomed Inform. 2010 Apr;43(2):208-17. Epub 2009 Sep 30. PubMed PMID: 19800027. |
| 2010 | 100 |
|
52 |
SpliceMinerhttp://projects.insilico.us/SpliceMiner/intro.jsp |
SpliceMiner is a tool for querying Evidence Viewer Database (EVDB). SpliceMiner supports high-throughput batch queries and provides results in an easily parsable format. |
| Kahn AB, Ryan MC, Liu H, Zeeberg BR, Jamison DC, Weinstein JN. SpliceMiner: a
high-throughput database implementation of the NCBI EvIDence Viewer for
microarray splice variant analysis. BMC Bioinformatics. 2007 Mar 5;8:75. PubMed
PMID: 17338820; PubMed Central PMCID: PMC1839109.
|
| 2007 | 100 |
1) Gene information includes chromosome number, start and end position, strand information. 2) Probe information includes Probe position. 1) Gene information includes chromosome number, start and end position, strand information. 2) Probe information includes Probe position. |
53 |
SplicePredictorhttp://deepc2.psi.iastate.edu/cgi-bin/sp.cgi |
Identifies potential splice sites in (plant) pre-mRNA. |
| | Not available | 100 |
1) Gives information about acceptor and donor site. 2) Gives information about site location and sequence. 3) Also gives information about the site quality. 4) Results can be obtained by e-mail. 1) Gives information about acceptor and donor site. 2) Gives information about site location and sequence. 3) Also gives information about the site quality. 4) Results can be obtained by e-mail. |
54 |
SpliceViewhttp://zeus2.itb.cnr.it/~webgene/wwwspliceview.html |
| | Not available | 100 |
The position of acceptor and donor site is given along with intronic and exonic sequence as well as score. The position of acceptor and donor site is given along with intronic and exonic sequence as well as score. |
55 |
SPLICY - VERSION 1.2http://host10.bioinfo3.ifom-ieo-campus.it/splicy/ |
| Rambaldi D, Felice B, Praz V, Bucher P, Cittaro D, Guffanti A. Splicy: a web-based tool for the prediction of possible alternative splicing events from Affymetrix probeset data. BMC Bioinformatics. 2007 Mar 8;8 Suppl 1:S17. PubMed
PMID: 17430561; PubMed Central PMCID: PMC1885846. |
| 2007 | 100 |
URL not working as on 14 Dec 2012 URL not working as on 14 Dec 2012 |
56 |
U12DB - U12 Intron Databasehttp://genome.crg.es/cgi-bin/u12db/u12db.cgi |
| Alioto TS. U12DB: a database of orthologous U12-type spliceosomal introns.
Nucleic AcIDs Res. 2007 Jan;35(Database issue):D110-5. Epub 2006 Nov 1. PubMed
PMID: 17082203; PubMed Central PMCID: PMC1635337.
|
| 2007 | 100 |
1) Didn't return any results with certain gene names like brca1 or mybl2. 2) Links to UCSC genome Browser is also given. 3) Intronic information is also given, such as junctions and sequence. 4) The donor, acceptor and branch point score is given under splice site details. 5) Gene information gives the description about the gene and the chromosome number. 1) Didn't return any results with certain gene names like brca1 or mybl2. 2) Links to UCSC genome Browser is also given. 3) Intronic information is also given, such as junctions and sequence. 4) The donor, acceptor and branch point score is given under splice site details. 5) Gene information gives the description about the gene and the chromosome number. |
57 |
X:Maphttp://xmap.picr.man.ac.uk |
| Yates T, Okoniewski MJ, Miller CJ. X:Map: annotation and visualization of
genome structure for Affymetrix exon array analysis. Nucleic AcIDs Res. 2008
Jan;36(Database issue):D780-6. Epub 2007 Oct 11. PubMed PMID: 17932061; PubMed
Central PMCID: PMC2238884. |
| 2008 | 100 |
|