Pharmacokinetics and Pharmacodynamics

RC - Resource Clinical
http://www.resourceclinical.com/

It is an online resource portal directory containing clinical pharmacy, clinical medicine and drug information links for the busy physician, pharmacist and other healthcare professionals.

KINETICS©
http://www.rxkinetics.com/kinetics.html

A database mainly designed by and for the practicing pharmacist and provides an easy to use pk dosing tool for adult patients.

Drugbank
http://www.drugbank.ca/

It is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

bear
http://pkpd.kmu.edu.tw/bear/

The data analysis tool for Average BioEquivalence (ABE) and BioAvailability (BA) for user.

Clinical pharmacology
http://www.clinicalpharmacology-ip.com/Forms/login.aspx?ReturnUrl=%2fdefault.aspx

It is a full database that covers drugs, investigational drugs, herbal products, nutraceuticals and nutritional products.

SIDER 2 - Side Effect Resource
http://sideeffects.embl.de/

Provides information about side effect frequency, drug and side effect classifications as well as links to further information.

PROMISCUOUS
http://bioinformatics.charite.de/promiscuous/

It is an exhaustive resource of protein-protein and drug-protein interactions, which aims to provide a uniform data-set for drug repositioning and its analysis and it contains three entities: proteins and side-effects as well as relations between them.

IUPHAR - The International Union of Basic and Clinical Pharmacology Database
http://www.iuphar-db.org/

Database of the IUPHAR Committee on receptor nomenclature and drug classification.

Berkeley Madonna
http://www.berkeleymadonna.com/

A database, which helps in constructing mathematical models for research and teaching.

DART - Drug Adverse Reaction Target
http://bidd.nus.edu.sg/group/drt/dart.asp

A database, which contains information about known drug adverse rection targets, functions and properties.

IDIS - Integrated Disbursement & Information System
http://itsnt14.its.uiowa.edu/

A database, which is developed to retrieve specific information about a drug and/or drug treatment of a disease state.

APIS
http://www.miips.fr/Cadre_produit_1.htm

It helps in model identification, stimulation and dosage regimen calculations in clinical and experimental pharmacokinetics.

BIOSOFT
http://www.biosoft.com/

A windows based scientific software package for a wide range of purposes like- data analysis, graph plotting, statistics, densitometry, dose-effect analysis, assays, curve-fitting, enzyme kinetics, teaching and more.

ADME - Absorption, Distribution, Metabolism, Excretion database (by aureus sciences)
http://www.aureus-sciences.com/aureus/web/guest/adme-overview

A database associated with known Absorption, Distribution, Metabolism, Excretion (ADME) properties, including human oral bioavailability, enzymes metabolism, inhibition and induction, transport, plasma protein binding and blood-brain barrier.

CalcuSyn
http://www.biosoft.com/w/calcusyn.htm

It is an analyzer of combined drug effects, and enables automatic quantification of phenomena like synergism and inhibition during mixed drug treatments.

Boomer
http://www.boomer.org/

Non-linear regression database for the analysis of pharmacokinetic and pharmacodynamic data.

ADME - Absorption, Distribution, Metabolism, Excretion databases (by UCSD)
http://modem.ucsd.edu/adme/databases/databases.htm

A database with six different databases, collected from literature related to drug discovery, Absorption, Distribution, Metabolism, Excretion (ADME) including water solubility (logS) datatabase, Caco-2 permeability database, blood-brain permeability database, P-gp inhibitor database, oral absorption database, oral bioavailability database and combined databases.

SAAM30 and CONSAM
http://septentrio.uit.no/index.php/rangifer/article/viewFile/819/785

Computer programs for performing non- linear regression analysis.

100

PDx-IVIVC
http://www.iconplc.com/services/preclinical-phase-i/

Provides information on the early-phase in clinical research, bioanalytical, PK/PD modeling & simulation.

100

PharmacoDynamics (PD) Plus
www.simulations-plus.com

Automated model selection that adds the pharmacodynamics table, which contains the PD model, the site of PD action, and the parameters that determine the kinetics of the action.

100

Phish Pharm
http://www.accessdata.fda.gov/scripts/SDA/sdNavigation.cfm?sd=PhishPharm

A searchable database of pharmacokinetics data in fish.

100

PHYSPROP - The physical properties database
http://www.srcinc.com/what-we-do/environmental/scientific-databases.html

A database, which contains chemical structures, names and physical properties for over 41,000 chemicals.

100

PK Solutions
http://www.summitpk.com/pksolutions/pksolutions.htm

ItA0is an automated excel-based program that does single and multiple dose pharmacokinetic data analysis of concentration-time data from biological samples (blood, serum,A0plasma, lymph, etc.) following intravenous or extravascular routes of administration.

100

PK/DB - DataBase for PharmacoKinetic properties
http://miro.ifsc.usp.br/pkdb/

A freely available database for pharmacokinetic properties and predictive in silico Absorption, Distribution, Metabolism, Excretion (ADME) models.

100

PKfit for R
http://cran.csie.ntu.edu.tw/web/packages/PKfit/index.html

It is an R package nonlinear regression (including a genetic algorithm) program, which was designed to perform model/curve fitting and model simulations for pharmacokinetics.

100

PK-Sim
http://www.systems-biology.com/products/pk-sim.html

A software tool for whole-body physiologically based pharmacokinetic modeling.

100

ADME-AP - Absorption, Distribution, Metabolism, Excretion -Associated Protein
http://bidd.nus.edu.sg/group/admeap/admeap.asp

It contains information aboutA0known drugA0Absorption, Distribution, Metabolism, Excretion (ADME) associated proteins, functions, similarities, substrates / ligands, tissue distributions, and other properties of the targets.

100

PROPKA
http://en.wikipedia.org/wiki/Protein_pKa_calculations

PROPKA is a heuristic pKaA0calculationA0software package developed by Jan Jensen at University of Copenhagen.

100

PubPk - the pK database
http://www.pubpk.org/index.php?title=Main_Page

A free online database for pharmacokinetics and phamacodynamics data including some articles.

100

RxMED
http://www.rxmed.com/

A database, which contains documented, authoritative and detailed information on over 3000 prescription pharmaceuticals that also includes general pharmacology, indications, warnings, dosage and adverse effects information for each pharmaceutical monograph.

100

NCI DIS 3D Database - The National Cancer Institute 3D Structure Database
http://dtp.nci.nih.gov/docs/3d_database/dis3d.html

It is a collection of 3D structures for over 400,000 drugs, which was built and is maintained by the developmental therapuetics program division of cancer treatment,A0national cancer institute.

100

acslXtreme
http://www.acslsim.com/

It helps in modeling, execution, and analysis environment for continuous dynamic systems and processes.

100

tdm for R
http://pkpd.kmu.edu.tw/tdm/

An R package for therapeutic drug monitoring.

100

TPNassist©
http://www.rxkinetics.com/tpn.html

AA0clinical toolA0mainly developed for pharmaceutical care, which combines comprehensive database functions and nutritional assessment into a single user-friendly package.

100

Transparency market research (Computational Biology )
http://www.transparencymarketresearch.com/computational-biology.html

It contains the information about pharmacodynamics, cellular modeling, computational genomics, proteomics, pharmacogenomics, pharmacokinetics, human simulation software, drug discovery & development.

100

TTD - Therapeutic Target Database
http://bidd.nus.edu.sg/group/ttd/ttd.asp

Therapeutic database, which contains information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status.

100

UKMi - UK Medicines Information
http://www.ukmi.nhs.uk/ukmi/about/default.asp?pageRef=1

A National Health Service (NHS) pharmacy based service, which aims to support the safe, effective and efficient use of medicines by the provision of evidence-based information and advice on their therapeutic use.

100

University of Washington pharmacokinetics laboratory
http://sop.washington.edu/pklab

A database that support both preclinical and clinical research protocols through the development and utilization of bioanalytical methods.

100

WinSAAM
http://www.winsaam.com/

Windows oriented modeling program enabling the user to explore biological systems using mathematical models.

100

WOMBAT PK
http://www.sunsetmolecular.com/index.php?option=com_content&view=article&id=16&Itemid=11

It contains clinical pharmacokinetic measurements; it further includes physico-chemical properties; toxicity endpoints, and annotated drug-target bioactivities.

100

Mathworks
http://www.mathworks.in/discovery/pharmacokinetic.html

A pharmacokinetics software tool for entireA0PharmacoKinetic and PharmacoDynamicA0workflow, from modeling to analysis, within a single graphical environment.

100

NONMEM®
http://www.iconplc.com/technology/products/nonmem/

It is an ICON's nonlinear mixed effects modelling tool. It is used in population pharmacokinetic and pharmacodynamic analysis and it was developed by University of California.

100

ADAPT II
http://legacy.samsi.info/201011/pkpd/SoftwareDZD.pdf

A computational toolA0for PK/PDA0modeling. It is also usedA0PK/PD dataA0analysisA0applications.

100

Duck flats pharma database
http://www.dfpharma.com/

It helps to set up and implement a strategic development plan focusing on the mechanism of action, efficacy and pharmacokinetics of the drug or biotechnology compound being developed.

100

Biotrial
http://www.biotrial.com/

It provides high-quality pharmacology services.

100

Biokmod web
http://www3.enusa.es/webMathematica/Public/biokmod.html

A program developed in Mathematica, web Mathematica and Java. It runs online and can be applied in pharmacokinetic, internal dosimetry and nuclear medicine.

100

Biokmod
http://web.usal.es/~guillermo/biokmod.htm

A mathematica toolbox for solving system of differential equations and for fitting coefficients with application for modeling Biokinetic systems and also includes the current International Commission on Radiological Protection (ICRP) biokinetic models, which can be applied in pharmacokinetic, internal dosimetry, bioassay evaluations, nuclear medicine and more.

100

Celerion
http://celerion.com/service/pharmacokineticspharmacodynamics-pkpd

A database, which includes PK and PD analysis and parameter calculation, study design input, written interpretation of PK and PD results for ICH study reports & consultation on PK/PD topics.

100

CEPKPD - Center of Excellence in Pharmacokinetics and Pharmacodynamics
http://pharmsci.buffalo.edu/CEPKPD/index.shtml

A database by University at Buffalo-SUNY(UB) to promote the development and application of PK/PD to the problems and challenges of drug therapy.

100

CHIME - Centre for Health Informatics & Multiprofessional Education
http://www.ucl.ac.uk/chime/

Database that support clinical practice and benefits the communities - both patients and health care professionals - locally, nationally and globally.

100

Bioeqv52, Biopar40 and Bioeqnew
http://www.sciencedirect.com/science/article/pii/0169260794901007

A0A software that performs bioequivalence calculations including statistical power.

100

Cloe Gateway
https://www.cloegateway.com/services/cloe_knowledge/pages/search.php

A leading provider of Absorption, Distribution, Metabolism, Excretion (ADME) screening and prediction services to the Pharmaceutical and Biotech industry.

100

CXT
http://www.boomer.org/pkin/cxt.html

It is a program for analysis of linear dynamic systems in the frequency domain.

100

URL not working as on 15 Nov 2016 (confirmed on 23 Feb 2017)

Cyber PatientTM
http://www.labsoft.com/www/software.html

A windows based multimedia PharmacoKinetic (PK) simulation program.

100

It is a pharmacokinetics program, which provides essential information to serve the practicing pharmacist.

100

Anti-cancer agent mechanism database
http://dtp.nci.nih.gov/docs/cancer/searches/standard_mechanism.html

A database, which contains a set of 122 compounds with anti-cancer activity and reasonably well known mechanism of action.

100

BIOPAK
http://andrewsforest.oregonstate.edu/data/tools/software/biopak.cfm?topnav=149

It is a menu-driven package of computer programs for personal computers that calculates the biomass, area, height, length, or volume of plant components (leaves, branches, stem, crown, and roots) and biomass by fuels size classes using existing prediction equations.

100

Gold standard drug database
http://www.goldstandard.com/product/gold-standard-drug-database/

A0An extensive and integrated drug database, which assists in taking intelligent drug decisions in every healthcare setting.

100

ICPD - Institute for Clinical PharmacoDynamics
http://www.icpd.com/

Assists pharmaceutical and biotechnology companies to provide safer and more effective drugs to patients through advanced methods of pharmacokinetic and pharmacodynamic system analysis.

100

It is a pharmacokinetics program without any patient database features and is currently being used at over 3000 sites worldwide.

100

Intellipharm PK
http://www.pharmaceuticalonline.com/doc/intellipharm-pk-0001

It is mainly developed for windows that simulates drug plasma concentrations based on drug's physical and pharmacokinetic parameters.

100

admetSAR
http://www.admetexp.org/

It is helpful forA0in silicoA0screeningA0Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) profiles of drug candidates and environmental chemicals.

100

ivivc for R
http://pkpd.kmu.edu.tw/ivivc/

A tool for inA0vitro-inA0vivo correlation.

100

JGuiB
http://pkpd.kmu.edu.tw/jguib/

A computer program that includes PK/PD modeling: normal fitting, stimulation and Bayesian estimation that is written in java work with boomer.

100

JPKD - JavaPK for Desktop
http://pkpd.kmu.edu.tw/jpkd/

It is a Clinical PharmacoKinetic (CPK) service (or Therapeutic Drug Monitoring (TDM)) computer program for desktop.

100

ADMEDB by FUJITSU
http://www.fqs.pl/chemistry_materials_life_science/products/adme_db

It is mainly designed for use in drug research and development, including drug-drug interactions and ADME (Absorption, Distribution, Metabolism and Excretion) studies that contain the latest and most comprehensive data on interactions of substances with drug metabolizing enzymes and drug transporters.

100

MacDope
http://openagricola.nal.usda.gov/Record/CAT88907258

A computer program by National Agricultural Library (NAL) mainly for Pharmacology, Pharmacokinetics, drugs and metabolism.

100

MedRoc
http://www.stenstat.com/

It is an integrated solution for performing ROC analyses of medical data.

100

mobilePK
http://pkpd.kmu.edu.tw/mobilepk/

A computer program designed for Clinical PharmacoKinetic (CPK) services (or Therapeutic Drug Monitoring, TDM)) running on Android mobile phone.

100